Introduction – Company Background
GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.
With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.
With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.
From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.
At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.
By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.
Core Strengths in Insole Manufacturing
At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.
Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.
We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.
With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.
Customization & OEM/ODM Flexibility
GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.
Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.
With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.
Quality Assurance & Certifications
Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.
We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.
Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.
ESG-Oriented Sustainable Production
At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.
To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.
We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.
Let’s Build Your Next Insole Success Together
Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.
From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.
Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.
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Latex pillow OEM production facility in Taiwan
Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.
With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Graphene cushion OEM production factory in Taiwan
Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.
We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Vietnam pillow ODM development service
At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.China OEM factory for footwear and bedding
📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Taiwan custom insole OEM factory
Proteins in human cells commonly undergo N-terminal acetylation, a modification by the enzyme group N-terminal acetyltransferases (NATs), the function of which has been largely mysterious. Recent research using CRISPR-Cas9 technology and collaborative studies in fruit flies reveal that this modification protects proteins from degradation, playing a crucial role in longevity and motility. Researchers have identified N-terminal acetylation as a crucial process that protects proteins from degradation, influencing longevity and mobility. Proteins are key to all processes in our cells and understanding their functions and regulation is of major importance. “For many years, we have known that nearly all human proteins are modified by a specific chemical group, but its functional impact has remained undefined,” says Professor Thomas Arnesen at the Department of Biomedicine, University of Bergen. He explains: “One of the most common protein modifications in human cells is N-terminal acetylation, which is an addition of a small chemical group (acetyl) at the starting tip (N-terminus) of a protein. The modification is launched by a group of enzymes called N-terminal acetyltransferases (NATs).” Despite being “everywhere” in human cells, the functional role of this modification remains mysterious, Arnesen explains. He is an investigator of a new study that reveals that a core function of this protein modification is to protect proteins from degradation, and this is essential for normal longevity and motility. CRISPR-Cas9 Technology Sheds New Light on N-Terminal Acetylation To address this question, molecular biologist and researcher Sylvia Varland spent two years at the Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Canada, supported by a FRIPRO mobility grant from the Research Council of Norway. Here, she used the established CRISPR-Cas9 technology and powerful screening platforms available in one of the best scientific environments to define the functional roles of the human NAT enzymes. Sylvia focused on one of the major human NAT enzymes, NatC, and the genome-wide screening of human NatC KO cells revealed many human genes likely to be involved in the function of N-terminal acetylation. Figure 1: N-terminal acetylation by NatC shields proteins from degradation. (Left) The NatC complex acetylates proteins harboring a hydrophobic residue in the second position (MΦ). Following Nt-acetylation, Ac-UBE2M and Ac-UBE2F promote cullin neddylation (N8), resulting in ubiquitylation (Ub) and proteasomal degradation of targeted cullin substrates, Ac-ARFRP1 is targeted to the Golgi where it plays a role in the secretory pathway, while the hypothetical proteins Ac-X and Ac-Y are thought to affect the secretory pathway and mitochondria, respectively. (Right) Loss of NatC exposes unacetylated MΦ-starting N-termini which serves as N-degrons that can be recognized by a set of N-recognins leading to proteasomal and, in some cases, lysosomal degradation. Non-Nt-acetylated NatC substrates are primarily targeted by the ubiquitin ligases UBR4-KCMF1 and to some extent UBR1 and UBR2. Targeted degradation of non-Nt-acetylated NatC substrates leads to decreased cullin neddylation, increased mitochondrial elongation, and fragmentation, and is thought to affect intracellular trafficking. (Figure from Varland, Sylvia et al, 2023, Nature Communications) Credit: Arnesen Lab, UiB “Without the inspiring scientific environment at the Donnelly Center combined with financial support from Marie Skłodowska-Curie Actions this study would not have seen the light of day,” says Varland. Back in the Arnesen lab at UiB, Sylvia explored the molecular implications of her genetic findings with the help of PhD student Ine Kjosås and other lab members. Biochemical, cell biology and proteomics experiments demonstrated that N-terminal acetylation acts as a shield to protect many proteins from protein degradation. Proteins lacking N-terminal acetylation were recognized by the cellular degradation machinery. “N-terminal acetylation has the power to dictate a protein’s lifetime and affects our cells in numerous ways,” says Varland. “This is true for humans, and it is also true in fruit flies, which is a very useful model to study this protein modification,” she continues. N-Terminal Acetylation Can Affect Aging In parallel, a research group by investigator Rui Martinho at the University of Aveiro in Portugal was working on the organismal impact of NatC-mediated N-terminal acetylation using a fruit fly model (Drosophila). Postdoctoral researcher Rui Silva and fellow students carried out studies with flies lacking N-terminal acetylation. The two teams decided to merge their efforts and have for the last two years coordinated their experiments. Flies lacking NatC were viable, but these flies displayed decreased longevity and decreased motility with age. These effects could be partially reversed by expressing a protein conserved between flies and humans found to be a key target of NatC protection. Decoding the NatC Puzzle In conclusion, using an unbiased and global genetic screen combined with cellular phenotyping, the team uncovered a general function for N-terminal acetylation in protecting proteins from degradation in human cells. The molecular investigations defined the cellular components (ubiquitin ligases) responsible for degrading a major class of human proteins when lacking N-terminal acetylation. The role of NatC-mediated protection of specific proteins is evident both in human cells and in fruit fly. The impact of these pathways on longevity and motility in aged individuals underscores the vital role of protein N-terminal acetylation. “This work untangles some of the secrets and shows how N-terminal acetylation shapes individual protein fate,” Thomas Arnesen concludes. Reference: “N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity” by Sylvia Varland, Rui Duarte Silva, Ine Kjosås, Alexandra Faustino, Annelies Bogaert, Maximilian Billmann, Hadi Boukhatmi, Barbara Kellen, Michael Costanzo, Adrian Drazic, Camilla Osberg, Katherine Chan, Xiang Zhang, Amy Hin Yan Tong, Simonetta Andreazza, Juliette J. Lee, Lyudmila Nedyalkova, Matej Ušaj, Alexander J. Whitworth, Brenda J. Andrews, Jason Moffat, Chad L. Myers, Kris Gevaert, Charles Boone, Rui Gonçalo Martinho and Thomas Arnesen, 27 October 2023, Nature Communications. DOI: 10.1038/s41467-023-42342-y The Norwegian part of this work was supported by research grants from the Research Council of Norway, the Norwegian Health Authorities of Western Norway, the Norwegian Cancer Society, and the European Research Council (ERC).
Researchers have mapped neurotransmitter receptors in the macaque brain, providing insights into how these ‘traffic lights’ control brain functions such as perception and emotion, potentially guiding future neurological treatments. The comprehensive data is available on the EBRAINS platform. (Artist’s concept.) Credit: SciTechDaily.com Scientists have mapped neurotransmitter receptors in macaque brains, discovering key organizational principles that help distinguish internal thoughts from external influences. The data, made publicly available, could provide valuable insights into brain activity, behavior, and drug interactions, and potentially guide the development of new treatments targeting specific brain functions. Receptor patterns define key organizational principles in the brain, scientists have discovered. An international team of researchers, studying macaque brains, has mapped out neurotransmitter receptors, revealing a potential role in distinguishing internal thoughts and emotions from those generated by external influences. The comprehensive dataset has been made publicly available, serving as a bridge linking different scales of neuroscience — from the microscopic to the whole brain. Lead author Sean Froudist-Walsh, from the University of Bristol’s Department of Computer Science, explained: “Imagine the brain as a city. In recent years, brain research has been focused on studying its roads, but in this research, we’ve made the most detailed map yet of the traffic lights — the neurotransmitter receptors — that control information flow. “We’ve discovered patterns in how these ‘traffic lights’ are arranged that help us understand their function in perception, memory, and emotion. “It’s like finding the key to a city’s traffic flow, and it opens up exciting possibilities for understanding how the normal brain works. “Potentially in the future, other researchers may use these maps to target particular brain networks and functions with new medicines. “Our study aimed to create the most detailed map yet of these ‘traffic lights’.” The team used a technique called in-vitro receptor autoradiography to map the density of receptors from six different neurotransmitter systems in over 100 brain regions. To find the patterns in this vast data, they applied statistical techniques and used modern neuroimaging techniques, combined with expert anatomical knowledge. This allowed them to uncover the relationships between receptor patterns, brain connectivity, and anatomy. Linking Receptors, Connectivity, and Anatomy By understanding the receptor organization across the brain, it is hoped new studies can better link brain activity, behavior, and the action of drugs. Moreover, because receptors are the targets of medicines, the research could, in the future, guide the development of new treatments targeting specific brain functions. Dr. Froudist-Walsh added: “Next, we aim to use this dataset to develop computational models of the brain. “These brain-inspired neural network models will help us understand normal perception and memory, as well as differences in people with conditions like schizophrenia or under the influence of substances like ‘magic mushrooms’. “We also plan to better integrate findings across species—linking detailed circuit-level neuroscience often conducted in rodents, to large-scale brain activity seen in humans.” Creating openly accessible maps of receptor expression across the cortex that integrate neuroimaging data could speed up translation across species. “It is being made freely available to the neuroscientific community via the Human Brain Project’s EBRAINS infrastructure, so that they can be used by other computational neuroscientists aiming to create other biologically informed models,” added Nicola Palomero-Gallagher, HBP researcher at the Forschungszentrum Jülich and senior author of the paper. Reference: “Gradients of neurotransmitter receptor expression in the macaque cortex” by Sean Froudist-Walsh, Ting Xu, Meiqi Niu, Lucija Rapan, Ling Zhao, Daniel S. Margulies, Karl Zilles, Xiao-Jing Wang and Nicola Palomero-Gallagher, 19 June 2023, Nature Neuroscience. DOI: 10.1038/s41593-023-01351-2 The global team of researchers are from University of Bristol, New York University, Human Brain Project, Research Center Julich, University of Dusseldorf, Child Mind Institute, and Universite Paris Cite.
Johns Hopkins University researchers highlight the potential of multispectral photoacoustic imaging in preventing nerve injuries during invasive medical procedures, identifying key wavelengths for optimal nerve visualization. Scientists investigate the unique absorption spectra of myelinated nerves as a way to visualize and differentiate them from their surroundings. Invasive medical procedures, such as surgery requiring local anesthesia, often involve the risk of nerve injury. During an operation, surgeons may accidentally cut, stretch, or compress nerves, especially when mistaking them for some other tissue. This can lead to long-lasting symptoms in the patient, including sensory and motor problems. Similarly, patients receiving nerve blockades or other types of anesthesia can suffer from nerve damage if the needle is not placed at the correct distance from the targeted peripheral nerve. Challenges in Current Imaging Techniques Consequently, researchers have been trying to develop medical imaging techniques to mitigate the risk of nerve damage. For instance, ultrasound and magnetic resonance imaging (MRI) can help a surgeon pinpoint the location of the nerves during a procedure. However, it is challenging to tell the nerves apart from surrounding tissue in ultrasound images, while MRI is expensive and time-consuming. Photoacoustic images of the ulnar (left) and median (right) nerves from a swine recorded in vivo for the first time. The nerves were illuminated with 1725 nm light and overlaid on co-registered ultrasound images. The outlines of the nerves and the surrounding agarose regions of interest (ROI) are shown as well. Credit: M. Graham et al., doi 10.1117/1.JBO.28.9.097001 The Promise of Photoacoustic Imaging In this regard, there is a promising alternative approach known as multispectral photoacoustic imaging. A noninvasive technique, photoacoustic imaging combines light and sound waves to create detailed images of tissues and structures in the body. Essentially, the target region is first illuminated with pulsed light, causing it to heat up slightly. This, in turn, causes the tissues to expand, sending out ultrasonic waves that can be picked up by an ultrasound detector. Recent Research from Johns Hopkins University A research team from Johns Hopkins University recently conducted a study in which they thoroughly characterized the absorption and photoacoustic profiles of nerve tissue across the near-infrared (NIR) spectrum. Their work, published on September 4 in the Journal of Biomedical Optics, was led by Dr. Muyinatu A. Lediju Bell, John C. Malone Associate Professor and PULSE Lab Director at Johns Hopkins University. One of the main objectives of their study was to determine the ideal wavelengths for identifying nerve tissue in photoacoustic images. The researchers hypothesized that the wavelengths from 1630–1850 nm, which reside within the NIR-III optical window, would be the optimal range for nerve visualization, since the lipids found in the myelin sheath of neurons have a characteristic absorption peak in this range. To test this hypothesis, they performed detailed optical absorption measurements on peripheral nerve samples. They observed an absorbance peak at 1210 nm, which fell in the NIR-II range. However, such an absorption peak is also present in other types of lipids. In contrast, when the contribution of water was subtracted from the absorbance spectrum, nerve tissue exhibited a unique peak at 1725 nm in the NIR-III range. Practical Testing and Implications Additionally, the researchers conducted photoacoustic measurements on the peripheral nerves of live swine using a custom imaging setup. These experiments further confirmed the hypothesis that the peak in the NIR-III band can be effectively leveraged to differentiate lipid-rich nerve tissue from other types of tissues and materials containing water or that are lipid-deficient. Satisfied with the results, Bell remarks: “Our work is the first to characterize the optical absorbance spectra of fresh swine nerve samples using a wide spectrum of wavelengths, as well as the first to demonstrate in-vivo visualization of healthy and regenerated swine nerves with multispectral photoacoustic imaging in the NIR-III window.” Overall, these findings could motivate scientists to further explore the potential of photoacoustic imaging. Moreover, the characterization of the optical absorbance profile of nerve tissue could help improve nerve detection and segmentation techniques when using other optical imaging modalities. “Our results highlight the clinical promise of multispectral photoacoustic imaging as an intraoperative technique for determining the presence of myelinated nerves or preventing nerve injury during medical interventions, with possible implications for other optics-based technologies. Our contributions thus successfully establish a new scientific foundation for the biomedical optics community,” concludes Bell. Reference: “Optical absorption spectra and corresponding in vivo photoacoustic visualization of exposed peripheral nerves” by Michelle T. Graham, Arunima Sharma, William M. Padovano, Visakha Suresh, Arlene Chiu, Susanna M. Thon, Sami Tuffaha and Muyinatu A. Lediju Bell, 4 September 2023, Journal of Biomedical Optics. DOI: 10.1117/1.JBO.28.9.097001
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